Robert Abramowitz - Cranbury NJ
Sunanda A. Ranadive - East Brunswick NJ
Sailesh A. Varia - Plainsboro NJ
Nemichand B. Jain - Cranbury NJ
Bristol-Myers Squibb Company - Princeton NJ
A three component pharmaceutical formulation of one or more pharmacologically active substances such that greater than 80% of the pharmacologically active substance will be released in the large intestine. The first component comprises the pharmacologically active substance, microcrystalline cellulose, a pH-sensitive polymer, and optionally an osmotic agent. The second component is a delayed release coating, and the third component is an enteric coating.