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Rama D Natarajan

from Hacienda Heights, CA
Age ~68

Rama Natarajan Phones & Addresses

  • 16837 Dawn Haven Rd, Hacienda Heights, CA 91745 (626) 333-7949
  • Ontario, CA
  • 16837 Dawn Haven Rd, Hacienda Heights, CA 91745 (626) 968-2234

Work

Position: Sales/Service

Education

Degree: Graduate or professional degree

Publications

Us Patents

Human Leukocyte 12-Lipoxygenase And Its Role In The Pathogenesis Of Disease States

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US Patent:
6893829, May 17, 2005
Filed:
Dec 20, 2000
Appl. No.:
09/739843
Inventors:
Jerry L. Nadler - Charlottesville VA,
Rama Natarajan - Hacienda Heights CA,
Assignee:
City of Hope - Duarte CA
International Classification:
C12Q002/26
G01N033/50
G01N033/573
G01N033/92
US Classification:
435 74, 435 25, 436 63, 436 71
Abstract:
The present invention relates to a method for inhibiting the etiology of disease in patients having a disease state caused by an excess of 12-lipoxygenase or its products. In particular, the invention provides for administration of a human leukocyte 12-lipoxygenase pathway inhibitor to inhibit disease etiology, to inhibit the proliferation of breast cancer and to increase insulin receptor phosphorylation in a patient having Type II diabetics.

Methods Of Suppression Of Rage Gene Expression And Rage Triggered Inflammatory Genes By Selected Age-Inhibitors

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US Patent:
8580854, Nov 12, 2013
Filed:
Nov 9, 2006
Appl. No.:
11/594981
Inventors:
Samuel Rahbar - Beverly Hills CA,
Rama Natarajan - Hacienda Heights CA,
Assignee:
City of Hope - Duarte CA
International Classification:
A61K 31/195
A61K 31/19
A01N 37/12
A01N 37/44
A01N 37/10
US Classification:
514563, 514571, 514566
Abstract:
Accelerated formation of advanced glycation/lipoxidation end products (AGEs/ALEs) has been implicated in the pathogenesis of various diabetic complications. Several natural and synthetic compounds have been proposed and tested as inhibitors of AGE/ALE formation. We have previously reported the therapeutic effects of several new AGE/ALE inhibitors on the prevention of nephropathy and dyslipidemia in streptozotocin (STZ)-induced diabetic rats. In this study, we investigated the effects of various concentrations of LR-90 on the progression of renal disease and its effects on AGE and receptor for AGE (RAGE) protein expression on the kidneys of diabetic STZ-rats. In vitro studies were also performed to determine if LR-90 could inhibit the expression of various pro-inflammatory mediators in human monocytic cells.

Mapping Histone Modifications By Dna Microarray

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US Patent:
2007029, Dec 20, 2007
Filed:
Aug 8, 2006
Appl. No.:
11/501662
Inventors:
Rama Natarajan - Hacienda Heights CA,
Feng Miao - Arcadia CA,
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
Many human diseases are now realized to have epigenetic features. Post-translational modification of histones plays a major role in these epigenetic features. Chromatin immunoprecipitation assay (ChIP) is currently the method of choice for localizing histone modifications in a step-wise fashion. This technique utilizes histone modification-specific antibodies to enrich DNA (ChIP DNA), followed by the use of promoter-specific primers to localize the modification. Methods of using DNA microarrays to screen ChIPed DNA are provided herein.

Human Leukocyte 12-Lipoxygenase And Its Role In The Pathogenesis Of Disease States

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US Patent:
6191169, Feb 20, 2001
Filed:
Nov 3, 1997
Appl. No.:
8/945744
Inventors:
Jerry L. Nadler - La Crescenta CA
Rama Natarajan - Hacienda Heights CA
Assignee:
City of Hope - Duarte CA
International Classification:
A61K 31195
A61K 31155
US Classification:
514562
Abstract:
The present invention relates to a method for inhibiting the etiology of disease in patients having a disease state caused by an excess of 12-lipoxygenase or its products. In particular, the invention provides for administration of a human leukocyte 12-lipoxygenase pathway inhibitor to inhibit disease etiology, to inhibit the proliferation of breast cancer and to increase insulin receptor phosphorylation in a patient having Type II diabetics.
Rama D Natarajan from Hacienda Heights, CA, age ~68 Get Report